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Menopause Or Not?

A MyBCTeam Member asked a question 💭
Leigh, UK

As we know chemo can bring on the menopause. In January my oncologist changed me from tamoxifen to letrozole because my bloods showed i was menopausal. when i saw her in April she said the bloods showed i was borderline? Has anyone else had this happen? I don't know if i'm coming or going with it! See her again next month to check again. I have the hot sweats that's all i know!

July 17, 2016
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A MyBCTeam Member

Elaine, I believe we were dx'ed about the same age and close to the same time. It's not such a bad thing to ensure that meno is complete at this stage, as recent study suggests (for premeno women) Tamoxafin for two to three years and then an ovarian ablation plus changeover to an AI proves the best possible course for risk reduction of local and distant return. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC369...(Phone number can only be seen by the question and answer creators)
Ask you Onco about this, as you might indeed be a candidate for ablation. I chose medical suppression rather than ooferectomy, but either work sufficiently.

((Hug))

July 17, 2016
A MyBCTeam Member

thankyou! i'm all discombobulated with it! she doesn't give any clues as to what or why. i just accepted the menopause was to come with the chemo,but now?

July 17, 2016
A MyBCTeam Member

Incidently, I felt what I thought was the full compliment of menopausal symptoms ( including profound cessation of periods) as a result of chemo; the flashes eventually subsided and periods never returned. I was SHOCKED, I tell you, to go through it again two years later when I began ovarian suppression and a switch to AI.

July 17, 2016
A MyBCTeam Member

Estrogen output from the ovaries can wax and wane as they fizzle out heading towards meno. Perhaps this is so for you, and your blood work is reflecting this. I think ( and I am a layperson) that an Onco usually would have three successive tests positve for meno before switching to an AI without considering a medical shutdown of the ovaries.
Provided your ovaries are NOT producing estrogen directly contributing to your serum level, AI's would do a pretty good job of blocking aromatase ( needed for conversion to estrogen) from your adrenals, fat and other sources, but, at least to date, Tamoxafin is the best to directly address estrogen from ovaries.

In my perimeno case, I was left on Tamoxafin for the first month of medical ovarian suppression before changing to an AI to make darn sure my ovaries were kaput before introducing said AI.
I'm hoping this might give you some clues with regard to wrapping your head around your present labs and what this might mean for you.
What does your Onco say about this? I wonder if she'll introduce a medical shutdown for a few months to get you through this flux so that you can maintain your AI.

((Hug))

July 17, 2016

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