It sounds as though you are struggling with pain. I am sorry you are going through this. I began getting stiffness and pain within 2 months of starting letrozole. I took a glucosamine supplement that included turmeric and boswellia My oncologist checked with the pharmacist who said that turmeric impacts the way the drug is metabolized making it stronger and worsening the side effects. I was also losing strength in my lower body. I took a two week medication break and switched to anastrozole. The side effects are not as dramatic for me. I still experienced pain and stiffness and used a glucosamine supplement (without turmeric and boswellia. Extreme fatigue has also been an issue. I eat a vegan plant based diet. Two weeks ago I stumbled upon a Hyper Nutrition Protocol which Involves adding one pound of raw cruciferous vegetables to the diet everyday. You can make smoothies if you don't want to eat salads or do both. You also drink a large amount of water. The amount recommended is too much for me. I drink about 68 ounces. This diet reduces the inflammation in the body. I just added this to my diet and continue to eat cooked foods (plants of course) I am feeling fantastic. No stiffness, pain or fatigue. I ran out of the glucosamine supplement two weeks ago and have not gone back to it. This is my personal experience. Always check with your health care provider . I hope that you will find something that will help you to feel better too.

Great question about the weight difference. I did have run one without AI and will take another one on it we will see the difference. I’ll let you guys know . I read that sometimes AI doesn’t even work for some . so there needs to be a read . There’s a level for prostate cancer why not breast cancer ?

Hello,
I have never had an Estrogen level tested. I looked up estrogen levels and found this:
The normal estrone (E1) level varies depending on the source.
Here are some examples of normal estrone levels:
Estrone (E1) Optimal Result: 12 - 26 ng/mg1.
Optimal Result: 4 - 16 ng/mg2.
In postmenopausal women, the normal range is about 14 to 103 pg/mL3.
In pregnant women, estrone levels can shoot up as high as 11,500 pg/mL3.
I will add this to my list for my next Medical Oncologist appointment.

Thanks everyone. This definitely sucks! Does anyone know what the increase in getting recurrence is if one does not take this medication.
I am struggling with the idea that I will feel like this for 10 years!

@A MyBCTeam Member - I know that increased cholesterol, high blood pressure, and joint and body aches are all things I was told by my doctor were possible side effects of anastrozole. And the list doesn't stop there. There are several possible impacts to eye health including cataracts, retinal hemorrhages, photopsia and increased incidence of floaters, as well as dry eye.

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