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ACT VS TC

A MyBCTeam Member asked a question 💭

Hello everyone. I just had lumpectomy for TNBC, stage 2a, 2.1 cm, no node involvement, negative margin. The doctor gave me 2 choices: ACT which supposed to increase survival rate to 3% and I'm just 52 y/o with potential cardiac side effect or secondary malignancy or TC. I am leaning towards TC. I already had prior rare parotid Ca and had chemo for that, I'm not sure if I want to risk a heart problem (it runs in my family) or secondary malignancy. I haven't started treatment yet. Any thoughts?

November 7, 2024
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A MyBCTeam Member

Maybe get a second opinion

November 8, 2024
A MyBCTeam Member

Choosing between ACT (Adriamycin, Cyclophosphamide, and Taxol) and TC (Taxotere and Cyclophosphamide) for treating triple-negative breast cancer (TNBC) can be challenging, especially with your medical history and family risk factors. Here are some considerations based on your situation:

- ACT
- Pros: May increase Show Full Answer

Choosing between ACT (Adriamycin, Cyclophosphamide, and Taxol) and TC (Taxotere and Cyclophosphamide) for treating triple-negative breast cancer (TNBC) can be challenging, especially with your medical history and family risk factors. Here are some considerations based on your situation:

- ACT:
- Pros: May increase survival rates by 3%.
- Cons: Potential cardiac side effects and risk of secondary malignancy, which is a concern given your family history of heart problems and previous chemotherapy for parotid cancer.

- TC:
- Pros: Generally considered to have fewer cardiac risks compared to ACT.
- Cons: May not offer the same increase in survival rate as ACT.

Given your age (52) and medical history, including prior chemotherapy and family history of heart issues, TC might be a safer option to avoid additional cardiac risks and secondary malignancies. However, it's crucial to discuss these concerns thoroughly with your oncologist to tailor the treatment plan to your specific needs and health profile.

November 7, 2024
A MyBCTeam Member

Ming, I had TC and had heart issues. You can have them with both products but the ACT is known to be worse and can be permanent.
In my case, I fainted 3x, had coronary heart spasms (mini heart attacks), chest angina and pin and needles all over arma and legs. I also had a drop in electrolytes (sodium and potassium) that was another danger for a heart attack. I stayed 2 days in the ER. High blood pressure.
I don’t mean to scare you as not everyone has this kind of reaction. But it can happen. It’s just that chemo is extremely heavy - there’s no way around this. Just try to be as mentally prepared as you can.
I had a friend who did first ACT and then continued with TC for TNBC. She didn’t have my side effects although it was pretty heavy on her too. But her tumor disappeared completely by surgery time and so she had a “pathological complete response” (pcr), which is great news with great prognosis. They still did the surgery but it was just empty shell of where thecancer had been. So, it is powerful and effective, but it will be heavy on your body. There’s also neuropathy which many people suffer from. You might have the the option to wear cold gloves and a cold cap to limit that and the hair loss. Ask more details from the nurse if you can. And have someone with you the first few days to a week after your first infusion to make sure they can bring you to the hospital if something goes wrong.

November 9, 2024 (edited)
A MyBCTeam Member

Thanks for the response. It would help if anyone who had undergone either treatment a while back would share their experience so at least newer dx like us would have someone to refer to.

November 8, 2024
A MyBCTeam Member

Hi Ming, if you have the slightest risk of having a heart problem, I would definitely avoid ACT. As far as I know, all chemos can cause a secondary cancer, whether ACT or TC or any other. Both choices won’t be easy on you, but Adriamicyn is the one that can cause irreversible heart damage.

November 8, 2024 (edited)

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