Verzenio is often used for those that are hormone positive, had Neo adjuvant chemo, and did not get complete pathological response. It is taken for 2 years.

Adding my information in case it helps others decide. I have been on it for 15 months. Started at 50 mg twice a day, went to 100 twice a day and couldn’t tolerate it, so I am back down to 50 twice a day. The side effects are noticeable, but not severe for me. I am extremely grateful to be able to take this drug as stage 2b with high KI 67 and high oncotypeDX score. I started anastrozole after lumpectomy, chemo and radiation, and a month later I started Verzenio.

Just completed week 41 of Verzenio. Biggest issue for me was fatigue. We stepped down the dose from 150 mg to 100 mg. I'm feeling great - like I did before diagnosis. There were many, many days when I did not think I would ever feel like myself again. GRATEFUL every day.

Wishing you well.

I have been on Verzenio 200mg twice a dayfor 4 weeks now. I had to have them decrease the dosage to 150mg twice a day & that seems to be better. Diarrhea & fatigue are real with this medication! I am also on Letrozole.
I am ER+ HER- Stage IIIa. I've done chemo, complete right mastectomy & am currently going through radiation. Today was session 8 of 33.

I started at 150mg 2x a day November 2023. I Down-dosed to 100mg last July and found it well tolerated. Fatigue was the symptom I didn't want to live with if the down-dose was still considered effect.

ER+ HERS-, HIGH KI 67 and high Oncotype, neoadjuvant chemo, double mastectomy and radiation.