Certainly! Here is some detailed information about ER/PR-positive and HER2-negative breast cancer based on the knowledge base:

ER/PR-Positive and HER2-Negative Breast Cancer

- Hormone Receptor Status
- ER-Positive: Cells contain estrogen receptors (ER).
- PR-Positive: Cells contain progesterone receptors (PR).
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Certainly! Here is some detailed information about ER/PR-positive and HER2-negative breast cancer based on the knowledge base:

ER/PR-Positive and HER2-Negative Breast Cancer

- Hormone Receptor Status:
- ER-Positive: Cells contain estrogen receptors (ER).
- PR-Positive: Cells contain progesterone receptors (PR).
- Hormone Receptor-Positive: Breast cancer cells contain ER, PR, or both.

- HER2 Status:
- HER2-Negative: Cells do not make too much of the HER2 protein.

- Treatment Implications:
- Hormonal Therapy: Since ER/PR-positive breast cancer cells rely on hormones to grow, hormonal therapy can be used to block the effects of these hormones. This helps slow or stop tumor growth.
- HER2-Targeted Therapies: Not applicable for HER2-negative breast cancer.

- How Hormonal Therapy Works:
- Hormonal therapy blocks natural hormones in the body and disrupts the growth process of hormone receptor-positive breast cancer cells.
- Some types of hormonal therapy attach to hormone receptors on the cell surface, preventing them from receiving growth signals.

Summary
ER/PR-positive and HER2-negative breast cancer is characterized by the presence of hormone receptors (ER and/or PR) and the absence of excess HER2 protein. Hormonal therapies are effective in treating this type of breast cancer by blocking the hormones that fuel cancer growth.

For more detailed information, you can refer to the following resources:
- [Hormonal Therapy for Breast Cancer](https://www.mybcteam.com/resources/hormonal-the...)
- [How (and Why) To Read Your Breast Cancer Pathology Report](https://www.mybcteam.com/resources/how-and-why-...)

If you have any more specific questions, feel free to ask!

 This AI-generated response comes from MyBCTeam and other selected sources. It is not a substitute for medical advice. Always ask your doctor about specific health concerns.

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